Academic Staff

                                        Daniele Suzete Persike de Oliveira
Daniele Suzete Persike de Oliveira None
Professor
Biochemistry/Neuroscience
  • Post-Doc in Neuroscience, Federal University of Sao Paulo (UIFESP, 2012), Brazil
    PhD in Molecular Pharmacology, University of Sao Paulo (USP, 2005), Brazil
    MSc in Biochemistry, Federal University of Parana (UFPR, 1999), Brazil
    BSc in Pharmacy and Biochemistry, Federal University of Parana (UFPR, 1997), Brazil

  • 1- Impact of Long-Term Cyclamate and Saccharin Consumption on Biochemical Parameters in Healthy Individuals and Type 2 Diabetes Mellitus Patients. Medicina. 2023 Apr 3;59(4):698.

    2- Adenosine A1 Receptor Agonist (R-PIA) before Pilocarpine Modulates Pro-and Anti-Apoptotic Factors in an Animal Model of Epilepsy. Pharmaceuticals 14.4 (2021): 376.

    3- Serendipitous discovery of phenylketonuria in Iraq–How to identify and treat? Molecular Genetics and Metabolism Reports. 2021 Jun;27.

    4- In vitro inhibition of blood cholinesterases by the organophosphate dichlorvos in typ-2 diabetic patients. Indian Journal of Forensic Medicine & Toxicology. 2021 May 17;15(3):3119-24.

    5- Blood cholinesterase activity and oxidative stress in type 2 diabetic patients. Rashid HM. Duhok medical journal. 2021 Apr 27;15(1):48-57.

    6- Challenges of post-traumatic stress disorder (PTSD) in Iraq: biochemical network and methodologies. A brief review. Horm Mol Biol Clin Investig. 2020 Nov 6;41(4). doi: 10.1515/hmbci-2020-0037. PMID: 33155990.

    7- Long-Term Saccharin Consumption and Increased Risk of Obesity, Diabetes, Hepatic Dysfunction, and Renal Impairment in Rats. Azeez, O.H.; Alkass, S.Y.; Persike, D.S. Medicina 2019, 55, 681. https://doi.org/10.3390/medicina55100681

    8- Altered Proteins in the Hippocampus of Patients with Mesial Temporal Lobe Epilepsy. Pharmaceuticals (Basel, Switzerland). 2018 Sep 30;11(4). pii: E95. doi: 10.3390/ph11040095. https://www.ncbi.nlm.nih.gov/pubmed/30274397

    9- Hippocampal Proteome of Rats Subjected to the Li-Pilocarpine Epilepsy Model and the Effect of Carisbamate Treatment. Pharmaceuticals (Basel). 2017 Jul 30;10(3). pii: E67. doi: 10.3390/ph10030067.

    10- Biochemical Mechanisms and Methodologies Applied to the Study of Posttraumatic Stress Disorder (PTSD). Paper: https://hmu.edu.krd/conferences/wp-content/uploads/2016/04/8.pdf

    11- Neuroprotective effects of peroxisome proliferator-activated receptor alpha and gamma agonists in model of parkinsonism induced by intranigral 1-methyl-4-phenyl-1,2,3,6-tetrahyropyridine. Behav Brain Res. 2014 Nov 1;274:390-9. doi: 10.1016/j.bbr.2014.08.014. Epub 2014 Aug 13.

    12- Reduced hippocampal manganese-enhanced MRI (MEMRI) signal during pilocarpine-induced status epilepticus: edema or apoptosis? Epilepsy Res. 2014 May;108(4):644-52. doi: 10.1016/j.eplepsyres.2014.02.007. Epub 2014 Feb 19.

    13- Consequences of pilocarpine-induced status epilepticus in immunodeficient mice. Brain Res. 2012 Apr 23;1450:125-37. doi: 10.1016/j.brainres.2012.02.028. Epub 2012 Feb 20.

    14- Differential neuroprotection by A(1) receptor activation and A(2A) receptor inhibition following pilocarpine-induced status epilepticus. Epilepsy Behav. 2011 Oct;22(2):207-13. doi: 10.1016/j.yebeh.2011.07.004. Epub 2011 Aug 17.

    15- Neuroprotective effect of pyruvate and oxaloacetate during pilocarpine induced status epilepticus in rats. Neurochem Int. 2011 Feb;58(3):385-90. doi: 10.1016/j.neuint.2010.12.014. Epub 2010 Dec 24.

    16- The A1 receptor agonist R-Pia reduces the imbalance between cerebral glucose metabolism and blood flow during status epilepticus: could this mechanism be involved with neuroprotection? Neurobiol Dis. 2011 Jan;41(1):169-76. doi: 10.1016/j.nbd.2010.09.004. Epub 2010 Sep 17.

    17- Acute and chronic exercise modulates the expression of MOR opioid receptors in the hippocampal formation of rats. Brain Res Bull. 2010 Oct 30;83(5):278-83. doi: 10.1016/j.brainresbull.2010.07.009. Epub 2010 Jul 23.

    18- Alteration of purinergic P2X4 and P2X7 receptor expression in rats with temporal-lobe epilepsy induced by pilocarpine. Epilepsy Res. 2009 Feb;83(2-3):157-67. doi: 10.1016/j.eplepsyres.2008.10.008. Epub 2008 Dec 12.

    19- Protective effect of the organotelluroxetane RF-07 in pilocarpine-induced status epilepticus. Neurobiol Dis. 2008 Jul;31(1):120-6. doi: 10.1016/j.nbd.2008.04.001. Epub 2008 Apr 23.

    20- Invertase and urease activities in the carotenogenic yeast Xanthophyllomyces dendrorhous (formerly Phaffia rhodozyma). Bioresour Technol. 2002 Mar;82(1):79-85.

    21- Carotenóides - Cores Atraentes e Ação Biológica. Biotecnologia Ciência & Desenvolvimento. , v.1, p.40 - 45, 2000.

    22- Cell Wall polysaccharides from Mandevilla velutina (Apocynaceae) cultured cells: extration and chemical struture. Carbohydrate Polymers. , v.12, p.1 - 7, 1999.

    Chapters of Books:

    1. FERNANDES, M. J. S., ROSIM, F. E., PERSIKE, D. S. Modelos Animais para o Estudo de Drogas Antiepilépticas e Uso da Imuno-histoquímica como Técnica Complementar In: Protocolos em psicofarmacologia comportamental: um guia para a pesquisa de drogas com ação sobre o SNC, com ênfase nas plantas medicinais. ed.São Paulo : Editora Fap-Unifesp, 2011, p. 231-266.

    2. “Underlying Mechanisms of Epilepsy. Chapter 7: Temporal Lobe Epilepsy: Cell Death and Molecular Targets”. ISBN: 978-953-307-765-9. Doi: https://doi.org/10.1007/978-1-4614-6464-8. https://www.intechopen.com/books/underlyingmechanisms-of-epilepsy.

    3. Fernandes, M.J.S.; Amorim, R.P.; Marques-Carneiro, J.E.; Araújo, M.G.L.; Persike, D.S. Chapter 8: “Proteomics-Based Strategy to Identify Biomarkers and Pharmacological Targets in Temporal Lobe Epilepsy”. In Pharmacoresistance in Epilepsy: from Genes and Molecules to Promissing Therapies. Springer, New York, NY. online ISBN 978-1-4614-6464-8.Print ISBN 978-1-4614-6463-1. https://link.springer.com/chapter/10.1007/978-1-4614-6464-8_8

    4. ROSIM, F. E., SILVA, I. R., PERSIKE, D. S., VIGNOLI, T., FERNANDES, M. J. S. ADENOSINA E NEUROPROTEÇÃO EM EPILEPSIA. In: Cinapce. ed.São Paulo : Pleiades, 2010, v.2, p. 193-197.

    5. FERNANDES, M. J. S., ROSIM, F. E., SILVA, I. R., PERSIKE, D. S., CAVALHEIRO, E. A. Papel Neuroprotetor da Adenosina na Epilepsia In: Tópicos de Actualización en Neurobiología. Excitotoxicidad y Cognición en Enfermedades Neurodegenerativas: Aspectos Básicos, Clínicos y Sociales.1 ed.Guadalajara : La Noche, 2010, v.1, p. 307-323.

    6. PERSIKE, D. S., ROSIM, F. E., FERNANDES, M. J. S. Pathophysiological aspects of temporal lobe epilepsy In: Epilepsy - A Review..1 ed.Patna : Bihar Chapter, 2010, v.1, p. 75-99.

    7. FERNANDES, M. J. S., ROSIM, F. E., PERSIKE, D. S., DONA, F. RECEPTORES PURINÉRGICOS E EPILEPSIA In: Epilepsia - Cinapce ed. São Paulo : Pleiades, 2010, v.2, p. 199-207.

  • Protein biochemistry (enzymology and proteomics), cell signaling and apoptosis, and biochemistry of neurological diseases. Search of new pharmacological active compounds obtained from medicinal plants. Currently has also been dedicated to the scientific advocacy of patients with rare metabolic diseases in Iraq.

  • 2017-present: University of Dohuk, College of Pharmacy, Department of Medicinal Chemistry, Iraq

    2012-2014: Lutheran University of Brazil (ULBRA), Tocantins, Brazil, College of Pharmacy.

    2006/2012: Federal University of Sao Paulo, UNIFESP, Brazil
    Department of Neurology and Neurosurgery Visiting Assistant Professor.
    Course "Update on Central Nervous System Diseases”.

    2000/2005: University Tuiuti of Parana, Parana, Brazil
    College of Pharmacy Assistant Professor of Biochemistry, Researcher and Member of the College Council

    1998-2000 Federal University of Parana
    Visiting Lecturer

    Other activities:

    2012-2014: College Council Member. Lutheran University of Brazil (ULBRA), College of Pharmacy.

    2010: Member of the Evaluation Commission Panel during the XXV Annual Meeting of the Federation of Societies of Experimental Biology - Fesbe.

    2003-2005: College Council Member. University Tuiuti of Parana / UTP, Brazil, College of Pharmacy.

    2000: Member of the Evaluation Commission of the papers presented at the Eighth Scientific Event Started - EVINCI. Universidade Federal do Paraná / UFPR.

    Research Projects:

    Present Colaboration: Pronex Thematic Project: A study using the proteomics method in rats submitted to pilocarpine-induced epilepsy after exposure to carisbamate.

    Present Colaboration: Proteomic evaluation in the human hippocampus of patients with temporal lobe epilepsy and chronic rats submitted to the pilocarpine epilepsy induction model.

    2012-2014: Evaluation of salivary alpha-amylase activity and its correlation with smoking and pharmacotherapy.

    2011: Expression of P2X and P2Y purinergic receptors in brain tissue during epileptogenesis: application of interfering methods (RNAi and pharmacological antagonists) in the characterization of the role of these receptors in temporal lobe epilepsy.

    2007-2009: Characterization of the purinergic system in temporal lobe epilepsy: an experimental model approach induced by pilocarpine.

    2006-2008: Characterization of pro and anti-apoptotic signaling in temporal lobe epilepsy.

    2001-2005: Analysis of the expression of genes, proteins and caspase enzymes in skeletal muscle cell culture and in animals submitted to the cancer - induced cachexia model.

    1997-1999: Extraction, purification and biochemical characterization of the ureolytic and saccharolytic enzymatic systems of Phaffia rhodozyma (Xanthophyllomyces dendrorhous).

  • Period: 2020-present. University of Dohuk, Iraq
    - Physiology and Biochemical Markers of Post-traumatic Stress Disorders.
    Sub-projects:
    1- Title: Correlation between post-traumatic stress disorder and hormonal imbalance in internal displaced people in Kurdistan Region/Iraq. PhD student: Kajeen Hassan Jasin.
    2- Title: Post-traumatic stress disorder: analysis of oxidative stress and inflammatory markers in internal displaced people living in Kurdistan region/Iraq. PhD student: Husni Muhammed Hasan.

    Co-supervisions:
    Period: 2017-2021. University of Dohuk, Iraq
    Thesis: Cholinesterase inhibition and its association with oxidative stress in type 2 diabetic patients. PhD student: Hussein Mohammed Rashid.
    Period: 2018-2019
    Thesis: Biochemical and genotoxic effect of aspartame or sodium saccharin with or without vitamin C or vitamin E in rats. PhD student: Omar Hassan Aziz Ali.

    2010-2012 Federal University of Sao Paulo, UNIFESP, SP, Brazil
    Co-Supervision :
    Michelle Gasparetti Lima: PhD in Neuroscience
    Thesis: Study of the role of P2X7 and P2Y1 receptors through blockade with specific antagonists in pilocarpine-induced epileptogenesis.
    Rebeca Padrão Amorim: PhD in Neuroscience Application of the RNA interference method in the characterization of the role of P2X7 receptor in temporal lobe epilepsy.

    2007-2009 Federal University of Sao Paulo, UNIFESP, SP, Brazil Supervisions:
    Danielli Souza Speciali: undergraduate research Study of the expression of purinergic P2X receptors in the hippocampus of patients with temporal lobe epilepsy. Priscilla Lima: undergraduate research Evaluation of neuronal death and HSP 72 expression in the brain of developing rats submitted to three episodes of status epilepticus by pilocarpine.

  • Period: 2020-present. University of Dohuk, Iraq
    - Physiology and Biochemical Markers of Post-traumatic Stress Disorders.
    Sub-projects:
    1- Title: Correlation between post-traumatic stress disorder and hormonal imbalance in internal displaced people in Kurdistan Region/Iraq. PhD student: Kajeen Hassan Jasin.
    2- Title: Post-traumatic stress disorder: analysis of oxidative stress and inflammatory markers in internal displaced people living in Kurdistan region/Iraq. PhD student: Husni Muhammed Hasan.

    Co-supervisions:
    Period: 2017-2021. University of Dohuk, Iraq
    Thesis: Cholinesterase inhibition and its association with oxidative stress in type 2 diabetic patients. PhD student: Hussein Mohammed Rashid.
    Period: 2018-2019
    Thesis: Biochemical and genotoxic effect of aspartame or sodium saccharin with or without vitamin C or vitamin E in rats. PhD student: Omar Hassan Aziz Ali.

    2010-2012 Federal University of Sao Paulo, UNIFESP, SP, Brazil
    Co-Supervision :
    Michelle Gasparetti Lima: PhD in Neuroscience
    Thesis: Study of the role of P2X7 and P2Y1 receptors through blockade with specific antagonists in pilocarpine-induced epileptogenesis.
    Rebeca Padrão Amorim: PhD in Neuroscience Application of the RNA interference method in the characterization of the role of P2X7 receptor in temporal lobe epilepsy.

    2007-2009 Federal University of Sao Paulo, UNIFESP, SP, Brazil Supervisions:
    Danielli Souza Speciali: undergraduate research Study of the expression of purinergic P2X receptors in the hippocampus of patients with temporal lobe epilepsy. Priscilla Lima: undergraduate research Evaluation of neuronal death and HSP 72 expression in the brain of developing rats submitted to three episodes of status epilepticus by pilocarpine.

  •   +9647502880486
      daniele.oliveira@uod.ac

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