Academic Staff

                                        Daniele Suzete Persike de Oliveira
Daniele Suzete Persike de Oliveira
Biochemistry and Pharmacology
  • - Postdoctorate in Neuroscience, Federal University of São Paulo  - UNIFESP, Brazil  (2012)

    • Course Abroad: 3rd and 4th Eilat International Course: Pharmacology of Treatment of Epilepsy, Israel - 2011 and 2009;

    - English Course Abroad: Connexion Training - Language and Cultural Training Programs. Atlanta, GA, USA. Duration: seven months.

    - PhD Pharmacology, University of São Paulo - USP, Brazil  (2005)

    - MSc Biochemistry , Federal University of Paraná - UFPR, Brazil (1999)

    - Graduated in Pharmacy, Federal University of Paraná - UFPR, Brazil (1997)


  • Most important publications:

    1- Altered Proteins in the Hippocampus of Patients with Mesial Temporal Lobe Epilepsy. Persike DS, Marques-Carneiro JE, Stein MLL, Yacubian EMT, Centeno R, Canzain M, Fernandes MJDS. Pharmaceuticals (Basel, Switzerland). 2018 Sep 30;11(4). pii: E95. doi: 10.3390/ph11040095.

    2- Hippocampal Proteome of Rats Subjected to the Li-Pilocarpine Epilepsy Model and the Effect of Carisbamate Treatment. Marques-Carneiro JE, Persike DS, Litzahn JJ, Cassel JC, Nehlig A, Fernandes MJDS. Pharmaceuticals (Basel). 2017 Jul 30;10(3). pii: E67. doi: 10.3390/ph10030067.

    3- Biochemical Mechanisms and Methodologies Applied to the Study of Posttraumatic Stress Disorder (PTSD). Paper: 

     4- Neuroprotective effects of peroxisome proliferator-activated receptor alpha and gamma agonists in model of parkinsonism induced by intranigral 1-methyl-4-phenyl-1,2,3,6-tetrahyropyridine. Barbiero JK, Santiago RM, Persike DS, da Silva Fernandes MJ, Tonin FS, da Cunha C, Lucio Boschen S, Lima MM, Vital MA. Behav Brain Res. 2014 Nov 1;274:390-9. doi: 10.1016/j.bbr.2014.08.014. Epub 2014 Aug 13.

    5- Reduced hippocampal manganese-enhanced MRI (MEMRI) signal during pilocarpine-induced status epilepticus: edema or apoptosis? Malheiros JM, Persike DS, Castro LU, Sanches TR, Andrade Lda C, Tannús A, Covolan L. Epilepsy Res. 2014 May;108(4):644-52. doi: 10.1016/j.eplepsyres.2014.02.007. Epub 2014 Feb 19.

    6- Consequences of pilocarpine-induced status epilepticus in immunodeficient mice. Vignoli T, Nehlig A, Massironi SG, Coimbra Rde C, Mazzacoratti Mda G, Silva IR, Neto EF, Persike DS, Fernandes MJ. Brain Res. 2012 Apr 23;1450:125-37. doi: 10.1016/j.brainres.2012.02.028. Epub 2012 Feb 20.

    7- Differential neuroprotection by A(1) receptor activation and A(2A) receptor inhibition following pilocarpine-induced status epilepticus. Rosim FE, Persike DS, Nehlig A, Amorim RP, de Oliveira DM, Fernandes MJ. Epilepsy Behav. 2011 Oct;22(2):207-13. doi: 10.1016/j.yebeh.2011.07.004. Epub 2011 Aug 17.

    8- Neuroprotective effect of pyruvate and oxaloacetate during pilocarpine induced status epilepticus in rats. Carvalho AS, Torres LB, Persike DS, Fernandes MJ, Amado D, Naffah-Mazzacoratti Mda G, Cavalheiro EA, da Silva AV. Neurochem Int. 2011 Feb;58(3):385-90. doi: 10.1016/j.neuint.2010.12.014. Epub 2010 Dec 24.

    9- The A1 receptor agonist R-Pia reduces the imbalance between cerebral glucose metabolism and blood flow during status epilepticus: could this mechanism be involved with neuroprotection? Silva IR, Nehlig A, Rosim FE, Vignoli T, Persike DS, Ferrandon A, Sinigaglia-Coimbra R, Fernandes MJ. Neurobiol Dis. 2011 Jan;41(1):169-76. doi: 10.1016/j.nbd.2010.09.004. Epub 2010 Sep 17.

    10- Acute and chronic exercise modulates the expression of MOR opioid receptors in the hippocampal formation of rats. de Oliveira MS, da Silva Fernandes MJ, Scorza FA, Persike DS, Scorza CA, da Ponte JB, de Albuquerque M, Cavalheiro EA, Arida RM. Brain Res Bull. 2010 Oct 30;83(5):278-83. doi: 10.1016/j.brainresbull.2010.07.009. Epub 2010 Jul 23.

    11- Alteration of purinergic P2X4 and P2X7 receptor expression in rats with temporal-lobe epilepsy induced by pilocarpine. Doná F, Ulrich H, Persike DS, Conceição IM, Blini JP, Cavalheiro EA, Fernandes MJ. Epilepsy Res. 2009 Feb;83(2-3):157-67. doi: 10.1016/j.eplepsyres.2008.10.008. Epub 2008 Dec 12.

    12- Protective effect of the organotelluroxetane RF-07 in pilocarpine-induced status epilepticus. Persike DS, Cunha RL, Juliano L, Silva IR, Rosim FE, Vignoli T, Dona F, Cavalheiro EA, Fernandes MJ. Neurobiol Dis. 2008 Jul;31(1):120-6. doi: 10.1016/j.nbd.2008.04.001. Epub 2008 Apr 23.

    13- Invertase and urease activities in the carotenogenic yeast Xanthophyllomyces dendrorhous (formerly Phaffia rhodozyma). Persike DS, Bonfim TM, Santos MH, Lyng SM, Chiarello MD, Fontana JD. Bioresour Technol. 2002 Mar;82(1):79-85.

    14- Carotenóides - Cores Atraentes e Ação Biológica. Fontana, J. D., Mendes, S. V., Persike, D. S., Peracetta, L. F., Passos, M.  Biotecnologia Ciência & Desenvolvimento. , v.1, p.40 - 45, 2000.

    15- Cell Wall polysaccharides from Mandevilla velutina (Apocynaceae) cultured cells: extration and chemical struture. Maraschim, M., Carobez, S. G., Persike, D. S., Peixoto, M. L., Ferreira, A. G., Ferracin, R., Verpoort, R., Fontana, J. D. Carbohydrate Polymers. , v.12, p.1 - 7, 1999.



    Chapters of Books:

    1. FERNANDES, M. J. S., ROSIM, F. E., PERSIKE, D. S. Modelos Animais para o Estudo de Drogas Antiepilépticas e Uso da Imuno-histoquímica como Técnica Complementar In: Protocolos em psicofarmacologia comportamental: um guia para a pesquisa de drogas com ação sobre o SNC, com ênfase nas plantas medicinais. ed.São Paulo : Editora Fap-Unifesp, 2011, p. 231-266.

    2.  “Underlying Mechanisms of Epilepsy. Chapter 7: Temporal Lobe Epilepsy: Cell Death and Molecular Targets”. ISBN: 978-953-307-765-9. Doi:

    3. Fernandes, M.J.S.; Amorim, R.P.; Marques-Carneiro, J.E.; Araújo, M.G.L.; Persike, D.S. Chapter 8: “Proteomics-Based Strategy to Identify Biomarkers and Pharmacological Targets in Temporal Lobe Epilepsy”. In Pharmacoresistance in Epilepsy: from Genes and Molecules to Promissing Therapies. Springer, New York, NY. online ISBN 978-1-4614-6464-8.Print ISBN 978-1-4614-6463-1.  

    4. ROSIM, F. E., SILVA, I. R., PERSIKE, D. S., VIGNOLI, T., FERNANDES, M. J. S. ADENOSINA E NEUROPROTEÇÃO EM EPILEPSIA. In: Cinapce. ed.São Paulo : Pleiades, 2010, v.2, p. 193-197.

    5. FERNANDES, M. J. S., ROSIM, F. E., SILVA, I. R., PERSIKE, D. S., CAVALHEIRO, E. A. Papel Neuroprotetor da Adenosina na Epilepsia In: Tópicos de Actualización en Neurobiología. Excitotoxicidad y Cognición en Enfermedades Neurodegenerativas: Aspectos Básicos, Clínicos y Sociales.1 ed.Guadalajara : La Noche, 2010, v.1, p. 307-323.

    6. PERSIKE, D. S., ROSIM, F. E., FERNANDES, M. J. S. Pathophysiological aspects of temporal lobe epilepsy In: Epilepsy - A Review..1 ed.Patna : Bihar Chapter, 2010, v.1, p. 75-99.

    7. FERNANDES, M. J. S., ROSIM, F. E., PERSIKE, D. S., DONA, F. RECEPTORES PURINÉRGICOS E EPILEPSIA In: Epilepsia - Cinapce ed. São Paulo : Pleiades, 2010, v.2, p. 199-207.

  • Protein biochemistry (enzymology and proteomics), cell signaling and apoptosis, and biochemistry of neurological diseases. Search of new pharmacological active compounds obtained from medicinal plants.


  • Present: Visiting Researcher and Professor. Depto of Medicinal Chemistry, College of Pharmacy, University of Dohuk.

    2012-2014: Adjunct Professor. Lutheran University of Brazil (ULBRA), College of Pharmacy.

    2006 - 2012:  Postdoctoral Researcher. Dept. of Neurology and Neurosurgery, Federal University of São Paulo (Unifesp).

    2001 - 2005: Assistant Professor. University Tuiuti of Paraná, Brazil,  Dept. of Pharmacy and Biochemistry,

    2000- 2003: Invited Professor. Federal University of Paraná (UFPR), Brazil, Dept. of Pharmacy, Postgraduate Program in Pharmaceutical Sciences.

    1999 - 2001: Assistant Professor. Federal University of Paraná (UFPR), Brazil, Dept. of Pharmacy and Biochemistry.




  • Post-graduate Supervision:

    2018: PhD thesis (co-supervisor): “CHOLINESTERASE INHIBITION BY ANTICHOLINESTERASE AGENTS IN TYPE 2 DIABETIC PATIENTS”. Student: Dr Hussein Mohammed Rashid. 


    2019: PhD thesis (co-supervisor): “Effect of prolonged consumption of artificial sweeteners on biochemical parameters in rats”. Student: Dr Omar Hasan Azeez. 

    2007: PhD Thesis - "Study of the expression of purinergic P2X receptors in the hippocampus of patients with temporal lobe epilepsy. Department of Neurology and Neuroscience - Escola Paulista de Medicina - UNIFESP, Student Fellowship of the National Council for Scientific and Technological Development (CNPq).

    2007: MSc Dissertation - "Evaluation of neuronal death and the expression of HSP 72 in developing rat brain subjected to three episodes of status epilepticus by pilocarpine. Department of Neurology and Neuroscience - Escola Paulista de Medicina - UNIFESP, Student Fellowship of the National Council for Scientific and Technological Development (CNPq).

  • Research Projects:

     Present Colaboration: Pronex Thematic Project: A study using the proteomics method in rats submitted to pilocarpine-induced epilepsy after exposure to carisbamate.

    Present Colaboration: Proteomic evaluation in the human hippocampus of patients with temporal lobe epilepsy and chronic rats submitted to the pilocarpine epilepsy induction model.

    2012-2014: Evaluation of salivary alpha-amylase activity and its correlation with smoking and pharmacotherapy. 

    2011: Expression of P2X and P2Y purinergic receptors in brain tissue during epileptogenesis: application of interfering methods (RNAi and pharmacological antagonists) in the characterization of the role of these receptors in temporal lobe epilepsy.

    2007-2009: Characterization of the purinergic system in temporal lobe epilepsy: an experimental model approach induced by pilocarpine.

    2006-2008: Characterization of pro and anti-apoptotic signaling in temporal lobe epilepsy.

    2001-2005: Analysis of the expression of genes, proteins and caspase enzymes in skeletal muscle cell culture and in animals submitted to the cancer - induced cachexia model.

    1997-1999: Extraction, purification and biochemical characterization of the ureolytic and saccharolytic enzymatic systems of Phaffia rhodozyma (Xanthophyllomyces dendrorhous).

    Other activities:

    2012-2014: College Council Member. Lutheran University of Brazil (ULBRA), College of Pharmacy.

    2010: Member of the Evaluation Commission Panel during the XXV Annual Meeting of the Federation of Societies of Experimental Biology - Fesbe.

    2003-2005: College Council Member. University Tuiuti of Parana / UTP, Brazil, College of Pharmacy.

    2000: Member of the Evaluation Commission of the papers presented at the Eighth Scientific Event Started - EVINCI. Universidade Federal do Paraná / UFPR.

    Honors and Awards:

    2009-2012 Postdoctoral Research Fellowship.
 Fundação de Amparo à Pesquisa no Estado de São Paulo (FAPESP), Brazil.  

    2008- Honorable Mention. Best work. Neuroprotective effect of adenosinergic A1 agonist (RPia), XXIII Annual Meeting of Fesbe (Federation of Brazilian Societies for Experimental Biology).  

    2008- Honorable Mention. Best poster presentation. Adenosinergic A1 agonist (R-Pia): modulation of caspases, XXIII Annual Meeting of Fesbe (Federation of Brazilian Societies for Experimental Biology).  

    2008- Award Aristides Leão. Best work. Neuroprotection and Epilepsy: The role of adenosinergic A1 agonist (R-Pia) in the modulation of the crisis induced by pilocarpine, Liga Brasileira de Epilepsia. 

    2006-2008 Postdoctoral Research Fellowship. Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), São Paulo, SP, Brazil. 

    2003-2005 PhD Research Fellowship, Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), São Paulo, SP, Brazil.  

    2004 Institutional Program of Education Upgrade (PRAE/CAPES) fellowship, São Paulo, SP, Brazil.  

    1997-1999 Master’s Fellowship, Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Curitiba, PR, Brazil.

    Recent Presentations as speaker at International Conferences: 

    1- "Posttraumatic Stress Disorder and its Biochemical Mechanisms: how to study it?” Conference: THE 1ST INTERNATIONAL ACADEMIC CONFERENCE ON GENOCIDE AT UOD, which was held by Besikci Center, on April 15-16, 2019. 

    2- “Biochemical Mechanisms & Methodologies Applied to the Study of Posttraumatic Stress Disorder”. Conference: 4th International Conference "Toward Scientific Identification of Mass Graves & Genocide in Kurdistan Region" which was held by HMU, on November 7-8, 2018. 

    3- Chairman at “Digestive Disease Day” organized by the College of Pharmacy under the  sponsorship of AstraZeneca, Rixos Hotel, Dohuk, Kurdistan Region, Iraq, 2018. 

    Recent Poster Presentation in International Conferences:

    1- “PRO- AND ANTIOXIDANT PROTEIN EXPRESSION IN MESIAL TEMPORAL LOBE EPILEPSY: A TRANSLATIONAL STUDY” Conference: 21st International Conference on Oxidative Stress Reduction, Redox Homeostasis and Antioxidants - Paris Redox 2019,  - organized at University Pierre et Marie Curie, Paris, France on June 20-21, 2019.  

    Projects in Development Between University and External Community:

    1- Started in 2019: “Cleaning your home eco-friendly”.  Recycling of cooking oil to make homemade preparations: cleaning bar soap and liquid detergent. Participants: students from the College of Pharmacy (under supervision and after receiving a training) and external communities such as villages and refugee camps. Purposes: 1- to reduce the environmental pollution by recycling cooking oil; 2- to teach the people living in the villages and refugee camps how to take benefit from the used cooking oil by using it to prepare cleaning bar soaps and liquid detergent. 

    2- Started in 2017: “Pharmaceutical Assistance to the Villages and Refugee Camps".  

    2.1- Pharmaceutical Assistance to Khanki Village, on June 26-27, 2018. 2.2- Pharmaceutical Assistance to Sharia Village, on June 21-22, 2017. 

    Recent Organization and presentation of workshop:  

    1- “Cleaning your home eco-friendly: Part 1 - Cleaning Bar Soaps made from used cooking oil”, on March 7, 2019. 2- “Cleaning your home eco-friendly: Part 2 - Liquid Detergent and Glycerin soaps”, on May 16, 2019. 3- “Homemade cough syrup”, on May 17, 2017.  

  •   00964 (0)750 288 0486;

  • Download